HGEN   501. Human Genetics. 3 Hours.

Semester course; 3 lecture hours. 3 credits. Open to qualified seniors and graduate students only. Provides a comprehensive examination of the fundamentals of human genetics. Explores topics including Mendelian and non-Mendelian inheritance, pedigree analysis, cytogenetics, aneuploid syndromes, cancer, gene structure and function, epigenetics, gene expression, biochemical genetics and inborn errors of metabolism. Crosslisted as: BIOL   530.

HGEN   502. Advanced Human Genetics. 3 Hours.

Semester course; 3 lecture hours. 3 credits. Prerequisite: HGEN   501 or equivalent. For human genetics graduate students only. A comprehensive study of the principles of specific areas in human genetics. Explores topics including quantitative genetics, genetic epidemiology, gene mapping, animal models, the characterization of complex disease, diagnostic testing and genetic counseling.

HGEN   510. Classic Papers in Human Genetics. 1 Hour.

Semester course; 1 lecture hour. 1 credit. Enrollment restricted to graduate students in the Department of Human and Molecular Genetics. This course surveys the seminal discoveries in the discipline of human genetics and introduces students to reading, understanding, discussing, critiquing and presenting original journal articles.

HGEN   511. Human Cytogenetics. 3 Hours.

Semester course; 3 lecture hours. 3 credits. Prerequisite: HGEN   501. A discussion of recent advances in human cytogenetics. Topics covered will include chromosome banding techniques and ultrastructure, meiosis, numerical and structural abnormalities, fragile sites, cancer cytogenetics, methodology for linkage studies, and population cytogenetics. Clinical cases are used to illustrate the application of special diagnostic methodologies.

HGEN   516. Population Genetics. 3 Hours.

Semester course; 3 lecture hours. 3 credits. Prerequisite: STAT/BIOS   543. Theoretical and empirical analyses of how demographic and evolutionary processes influence neutral and adaptive genetic variation within populations. Crosslisted as: BIOL   516.

HGEN   517. Introduction to R Programming for Statistical Genetics. 1 Hour.

Semester course; 1 lecture hour. 1 credit. Open only to graduate students or by permission of course director. This course is to provide and introduction to statistical programming in R. Lectures will provide the fundamentals for efficient handling and exploration of common data set structures in genetic and biomedical sciences.

HGEN   525. Practice of Genetic Counseling. 3 Hours.

Continuous courses; 3 lecture hours. 3-3 credits. Enrollment restricted to genetic counseling master’s students. Provides context for practice of genetic counseling through literature review and practical techniques. Places specific emphasis on pregnancy and childhood evaluation, interviewing techniques, social and ethical issues, including fieldwork in prenatal, general genetics and specialty clinics.

HGEN   526. Practice of Genetic Counseling. 3 Hours.

Continuous courses; 3 lecture hours. 3-3 credits. Enrollment restricted to genetic counseling master’s students. Provides context for practice of genetic counseling through literature review and practical techniques. Places specific emphasis on pregnancy and childhood evaluation, interviewing techniques, social and ethical issues, including fieldwork in prenatal, general genetics and specialty clinics.

HGEN   527. Medical Genetics. 3 Hours.

Continuous courses; 3 lecture hours. 3-3 credits. Prerequisite: HGEN   525-526 or permission of instructor. Enrollment restricted to genetic counseling master’s students. Provides medical information and principles of human genetic disease with specific emphasis on the molecular basis of Mendelian disorders, disorders of sexual development, assessment of dysmorphic features, and the genetics of common diseases. Emphasizes the use of all available resource materials in genetics.

HGEN   528. Medical Genetics. 3 Hours.

Continuous courses; 3 lecture hours. 3-3 credits. Prerequisite: HGEN   525-526 or permission of instructor. Enrollment restricted to genetic counseling master’s students. Provides medical information and principles of human genetic disease with specific emphasis on the molecular basis of Mendelian disorders, disorders of sexual development, assessment of dysmorphic features, and the genetics of common diseases. Emphasizes the use of all available resource materials in genetics.

HGEN   600. Clinical Genetics. 3 Hours.

Semester course; 1 lecture and 4 laboratory hours. 3 credits. Enrollment restricted to genetic counseling master’s students. Practical experience in the genetic counseling clinic and on ward rounds. Includes collection and analysis of family histories, genetic counseling, and introduction to genetic nosology.

HGEN   602. Genetic Models of Disease. 3 Hours.

Semester course; 3 lecture hours. 3 credits. Understanding the molecular basis of human disease states is a major focus for biomedical research. This course will train students to investigate molecular-genetic mechanisms of disease using four genetic model organisms: the nematode C. elegans, the fruit fly Drosophila melanogaster, the teleost zebrafish Danio rerio and the mouse Mus musculus, which serve as important laboratory models for human diseases and facilitate the elucidation of the underlying molecular mechanisms.

HGEN   603. Mathematical and Statistical Genetics. 3 Hours.

Semester course; 3 lecture hours. 3 credits. Prerequisites: BIOS   543-544, equivalent or permission from course director. Provides an introduction to the rudiments of theoretical and applied mathematical population genetics including the segregation of genes in families, genetic linkage and quantitative inheritance. Emphasizes the methods used in the analysis of genetic data.

HGEN   605. Experimental Methods in Human Genetics. 1-3 Hours.

Semester course; 2-6 laboratory hours. 1-3 credits. Restricted to students in the M.S. or Ph.D. programs in human genetics. Provides hands-on experience with the experimental methods that are used to carry out research in specific areas of human genetics prior to beginning thesis/dissertation research. Graded S/U/F.

HGEN   606. Introduction to Clinical Genetics. 1 Hour.

Semester course; 1 lecture hour. 1 credit. Prerequisite: open only to graduate students in human genetics programs or by permission of instructor. Provides an overview of medical genetics and counseling practice for non-genetic counseling students, including orientation to the translational side of research genetics and contemporary practice of clinical genetics. Graded S/U/F.

HGEN   610. Current Literature in Human Molecular Genetics. 1 Hour.

Semester course; 1 lecture hour. 1 credit. Prerequisite: open only to graduate students. Provides directed experience in critiquing, understanding and presenting current literature on a focused topic in molecular genetics. Graded as S/U/F.

HGEN   614. Pathogenesis of Human Genetic Disease. 3 Hours.

Semester course; 3 lecture hours. 3 credits. Prerequisites: BIOC   503 or BIOC   530-533 and BIOC   504, equivalent, or permission of instructor. Surveys the mechanisms and varieties of human gene mutations resulting in human genetic disease and emphasizes different investigational disorders using current scientific literature.

HGEN   617. Genetic Analysis of Complex Traits. 3 Hours.

Semester course; 3 lecture hours. 3 credits. Prerequisite: introductory biostatistics or permission of instructor. Introduces the theory and practice of analysis of complex human traits. Provides a solid grounding in the fundamental concepts, study designs and analytical strategies for this evolving and important area.

HGEN   619. Quantitative Genetics. 3 Hours.

Semester course; 3 lecture hours. 3 credits. The effects of genes and environment on complex human traits with emphasis on: Genetic architecture and evolution; nongenetic inheritance; mate selection; developmental change; sex-effects; genotype-environment interaction; resolving cause from effect; design of genetic studies, statistical methods and computer algorithms for genetic data analysis.

HGEN   620. Principles of Human Behavioral Genetics. 3 Hours.

Semester course; 3 lecture hours. 3 credits. The theory of genetic and nongenetic transmission considered in relation to the design, analysis, and interpretation of studies to identify the principal genetic and environmental causes of behavioral variation. Included will be analysis of intelligence, personality, social attitudes, and psychiatric disorders.

HGEN   622. Cancer Genetic Counseling. 3 Hours.

Semester course; 3 lecture hours. 3 credits. Prerequisite: HGEN   501-502 or permission of instructor. Provides a background in as well as the most current information relevant to cancer genetics and cancer genetic counseling. Includes instruction in basic science and genetic and psychosocial aspects of cancer, with an emphasis on familial and hereditary cancers.

HGEN   631. Advanced Dental Genetics. 1 Hour.

Semester course; 1 lecture hour. 1 credit. Enrollment is limited to students in the DDS program. A 1 credit hour course on topics in human genetics with application to clinical dentistry.

HGEN   690. Genetics Research Seminar. 1 Hour.

Semester course; 1 lecture hour. 1 credit. Selected topics in genetics presented by students and staff.

HGEN   691. Special Topics in Genetics. 1-4 Hours.

1-4 credits. Lectures, tutorial studies, library assignments in selected areas of advanced study or specialized laboratory procedures not available in other courses or as part of the research training.

HGEN   692. Special Topics. 1-4 Hours.

Semester course; 1-4 variable hours. 1-4 credits. Lectures, tutorial studies, library assignments in selected areas of advanced study or specialized laboratory procedures not available in other courses or as part of the research training. Graded as S/U/F.

HGEN   697. Directed Research in Genetics. 1-15 Hours.

1-15 credits. Research leading to the M.S. or Ph.D. degree and elective research projects for other students.