Henry J. Donahue, Ph.D.
Professor and chair
The Department of Biomedical Engineering offers programs at the baccaluareate, master’s and doctoral level.
Biomedical engineering provides in-depth study in a variety of specialization areas including biomedical imaging systems, orthopaedic biomechanics, tissue and cellular engineering, biomaterials, artificial organs, human-computer interfaces, cardiovascular devices, rehabilitation and human factors engineering. The programs allow students to participate in cutting-edge research in one of the nation’s most advanced engineering facilities. The department has ongoing collaborations with numerous industries, federal laboratories, the VCU science departments, the university’s MCV Campus, the Hunter Holmes McGuire Veterans Affairs Medical Center, the Virginia BioTechnology Research Park and numerous biomedical and clinical programs throughout the VCU Medical Center’s MCV Hospitals.
EGRB 507. Biomedical Electronics and Instrumentation. 3 Hours.
Semester course; 2 lecture and 2 laboratory hours. 3 credits. Fundamental principles and applications of electronics and instrumentation as related to biomedical sciences.
EGRB 509. Microcomputer Technology in the Biomedical Sciences. 3 Hours.
Semester course; 2 lecture and 2 laboratory hours. 3 credits. Microcomputer applications to the acquisition and manipulation of data in the biomedical laboratory.
EGRB 511. Fundamentals of Biomechanics. 3 Hours.
Semester course; 3 lecture hours. 3 credits. Prerequisites: Calculus and ordinary differential equations (MATH 200-201, MATH 301 or equivalent). Presents basic mechanical properties of materials, describes methods of material testing and introduces techniques for analyzing the solid and fluid mechanics of the body. Considers topics such as stress/strain relationships, particle mechanics, and force balances.
EGRB 517. Cell Mechanics and Mechanobiology. 3 Hours.
Semester course; 3 lecture hours. 3 credits. Prerequisites: previous course in biomechanics and a previous cell biology course, or permission of instructor. Graduate-level students will gain a quantitative understanding of cellular mechanics and the way cells detect, modify and respond to the physical properties within the cell environment. Students will gain a thorough understanding of relevant primary literature and mathematical models. Both experimental and theoretical approaches toward cell mechanics and mechanobiology will be addressed. Emphasis will be placed upon cells from the nervous, cardiovascular and pulmonary systems. Cancer cell mechanotransduction will also be addressed.
EGRB 603. Biomedical Signal Processing. 3 Hours.
Semester course; 3 lecture hours. 3 credits. Prerequisites: Calculus and differential equations (MATH 301 or equivalent), including Laplace and Fourier Transforms. Explores theory and application of discrete-time signal processing techniques in biomedical data processing. Includes discrete-time signals and systems, the Discrete/Fast Fourier Transforms (DFT/FFT), digital filter design and implementation, and an introduction into processing of discrete-time random signals.
EGRB 610. Microprocessor Interfacing for Biomedical Instrumentation. 3 Hours.
Semester course; 2 lecture and 2 laboratory hours. 3 credits. Prerequisite: EGRB 509 or permission of instructor. Principles and applications of microprocessor interfacing for biomedical instrumentation. Topics include microprocessor architecture, assembly language, programming and debugging techniques, EPROM programming and bus structure and interfacing.
EGRB 611. Cardiovascular Dynamics. 3 Hours.
Semester course; 3 lecture hours. 3 credits. Pre- or corequisite: PHIS 501 or PHIS 502. Analyzes and models the cardiovascular system in health and disease through studies on the properties of heart and vascular tissue, the mechanics of blood flow and the application of engineering methods to the diagnosis and treatment of cardiovascular pathologies.
EGRB 612. Structural Biomechanics. 3 Hours.
Semester course; 3 lecture hours. 3 credits. Prerequisite: EGRB 511. Treats mechanical functions of the human body as an engineering structure used to assist and supplement these functions. Includes movement of the musculoskeletal system, joint reaction forces, stresses and strains developed within bones, function and design of orthopedic prostheses and braces, effect of vibration and impact on the body, mathematical and other models of the body.
EGRB 613. Biomaterials. 3 Hours.
Semester course; 3 lecture hours. 3 credits. Prerequisite: Undergraduate material science or permission of the instructor. Primary and secondary factors determining the performance of materials used for implants in the human body. Topics will include metallurgy of stainless steel, cobalt-chromium alloys, titanium alloys, biocompatibility of implant materials, mechanical and physical properties of biomaterials, corrosion of biomaterials and medical polymers.
EGRB 615. Medical Imaging. 3 Hours.
Semester course; 3 lecture hours. 3 credits. Prerequisite: Calculus and college physics. Covers the physical principles and techniques of medical imaging modalities such as ultrasound, X-ray and nuclear magnetic resonance. Includes generation and detection of images, consideration of system design and qualitative image analysis.
EGRB 616. Cell Engineering. 3 Hours.
Semester course; 3 lecture hours. 3 credits. Prerequisite: PHIS 501. This course will cover the cell and its engineering principles with an emphasis on current research techniques. Topics covered include the organization and structure of the cell, cell signaling, and application of cell biology to biomedical research. Advanced methods are taught enabling students to interpret and present findings from primary literature.
EGRB 618. Regenerative Engineering and Medicine. 3 Hours.
Semester course; 3 lecture hours. 3 credits. Prerequisite: undergraduate or graduate level physiology or permission of instructor. Study of the design, development and clinical application of regenerative medicine strategies. Analysis of molecular and cellular engineering, biomaterials and tissue engineering, stem cell biology, and immunology as they pertain to pre-translational and clinically used regenerative medicine therapies, as well as the regulatory and ethical considerations of their implementation.
EGRB 619. Computational and Experimental Models of Cellular Signal Transduction. 3 Hours.
Semester course; 3 lecture hours. 3 credits. Corequisite: EGRB 616 or permission of instructor. In this course students will study the process by which an extracellular protein binding event is transduced and interpreted as an incoming signal into a cell. Students will learn the biology of cellular signal transduction, as well as how to apply computational models and experimental techniques to predict and investigate these pathways. The course will follow the course of a protein within a signal transduction cascade, from binding to a receptor, activating intracellular pathways, inducing new transcription and translation, and targeting of the protein to its final location. Students will develop MATLAB-based mathematical models to predict signal transduction dynamics and then study experimental techniques that are used to both disrupt and measure signal transduction.
EGRB 635. Modeling for Biomedical Engineers. 3 Hours.
Semester course; 3 lecture hours. 3 credits. Prerequisite: Permission of instructor. Applies mathematical modeling techniques to biomedical systems. Covers linear and nonlinear systems, deterministic and random systems, large systems, ecosystems, numerical techniques, graph theoretical approaches and simulation packages. Utilizes examples of biochemical, physiological and pharmacokinetic systems throughout.
EGRB 670. Advanced Molecular Modeling Theory and Practice. 3 Hours.
Semester course; lecture and laboratory hours. 3 credits. Prerequisite: MEDC 641, EGRB 641 or permission of the instructor. Examines the principles and applications of computational chemistry and molecular graphics to current problems in drug design. Lectures focus on the application of specific computational methods and techniques to solve problems in drug/molecular design. Workshop sessions provide hands-on experience using state-of-the-art hardware and software for molecular modeling.
EGRB 690. Biomedical Engineering Research Seminar. 1 Hour.
Semester course; 1 lecture hour. 1 credit. Presentation and discussion of research reports and topics of current interest to the program seminar or special group seminar.
EGRB 691. Special Topics in Biomedical Engineering. 1-4 Hours.
Semester course; 1-4 credits. Lectures, tutorial studies, library assignments in selected areas of advance study, or specialized laboratory procedures not available in other courses or as part of the research training.
EGRB 697. Directed Research in Biomedical Engineering. 1-15 Hours.
Semester course; 1-15 credits. Research leading to the M.S. degree or elective research projects for other students.