CLSE 675. Polymers in Medicine. 3 Hours.

Semester course; 3 lecture hours. 3 credits. This course is based on the need for integration of engineering and materials science of polymers with applications in life science engineering. Basic principles of polymer science including structural concepts at the molecular-, nano-, micro- and macro-scales are emphasized so that the student can understand structure/function correlation. The course treats polymer synthesis, molecular weight, morphology and surface science at an introductory level, but quantitative correlations are emphasized. Surface science is emphasized, as medical applications are often dependent on the interaction of a solid polymer with an in vivo environment (tissue, blood, membrane). The polymers chosen for emphasis include polyethylene (hip, knee replacement), poly(vinylchloride) (bood bags, catheters), polyurethanes (artificial heart, wound care) and silicones (implants, catheters). The use of polymers in drug delivery applications is explored, including osmotic-pressure-driven drug delivery. Concepts surrounding polymeric surface modifiers are developed, including applications such as enhanced biodurability and biocidal function.