The faculty and administrative offices of the school are housed at 1100 E. Leigh St. Additionally, this building has a nursing clinical resource laboratory and classrooms equipped with a full range of audiovisual equipment. Both graduate and undergraduate courses are also scheduled in other classrooms on campus.

The clinical laboratories for nursing courses are conducted at the VCU Medical Center and in numerous other urban and rural hospitals and health agencies in the area, including community medical centers and state hospitals, public health services, private clinics and offices, and federal and state centers and departments. These facilities provide generalized and specialized inpatient and ambulatory services. Students are given a range of diverse experiences in hospital and community-oriented nursing. Selection of specific facilities for student experience is based upon curricular and advanced-practice certification requirements, the educational needs of the individual student and the services available.