Graduate study in the Department of Human and Molecular Genetics in the School of Medicine is a highly individualized undertaking and required course work represents only one component. Each student’s program is tailored to meet his or her particular interests, with the primary emphasis on developing research skills and the capacity for independent scholarship and with the recognition that career goals for many M.D.-Ph.D. physician-scientists are distinct from those of most Ph.D. trainees.
The objectives of this dual degree program are:
- Students in the M.D.-Ph.D. program in human genetics will acquire the foundational skills to allow them, after further clinical specialty and postdoctoral research training, to become independent physician-scientists. Program graduates ultimately pursue careers in academic medicine, biotechnology and pharmaceutical industry, research institutes and government agencies as clinicians, scientists, educators and administrators.
- Students will gain a progressive mastery of concepts in human genetics and related disciplines, an understanding of the current state of research investigations in the field, an ability to synthesize information and apply foundational concepts to identify key areas for innovative investigation and experimentation, and the knowledge to design, execute and interpret experiments and publish studies that address the questions identified.
- Students will develop skills in various means of communicating core knowledge in the field and the details of experimental design, results and interpretation to a variety of potential audiences.
Among the many benefits offered by participation in the dual-degree program are the following:
- Students will have the foundation and training in human genetics and in medicine to conduct basic and translational research that will enable them to take bedside observations to the bench and the results of bench research to the bedside to advance both the underlying science and patient health.
- Students have the opportunity to participate in clinical research during the M4 year.
- Students with M.D.-Ph.D. training are highly competitive for positions in leading physician-scientist clinical training programs, faculty positions in academic medical centers, and are well-positioned to ultimately take on leadership roles in academic medicine, industry and government.
- Tuition, fees and a stipend are provided throughout both the medical and graduate phases of training.
The diplomas for this dual degree program are awarded simultaneously upon completion of the requirements for both degrees.
Student learning outcomes
The student learning outcomes described on the human genetics Ph.D. program page also apply to M.D.-Ph.D. students.
To be considered for the VCU M.D.-Ph.D. program, prospective students must apply to the medical school through the American Medical College Application Service. Please designate “Combined Graduate/Medical Degree” on your AMCAS application. The deadline for application to the program for admission in the fall semester is listed on the AMCAS web site.
In rare situations when resources allow, students matriculated in the medical school class may be considered for admission to the M.D.-Ph.D. program, usually near the start of the M1 academic year. For additional details, see the M.D.-Ph.D. dual degree opportunities page.
The dual degree program is designed to allow students to complete the first two years of medical school and the USMLE Step 1 examination (M1, M2) before undertaking graduate training (G1 and subsequent years). After successfully defending the Ph.D. dissertation, students complete the remaining clinical years (M3, M4) of medical training. Nevertheless, important aspects of dual degree training are integrated across the program. These include M.D.-Ph.D.-specific graduate courses taken during M1 and M2 that supplement the medical curriculum and emphasize research and translational aspects of M.D. course topics and required M3 clinical rotations integrated into the graduate phase. Opportunities for research experience begin prior to entering the graduate phase (pre-matriculation and summers after M1 and M2), when students spend time working in several faculty laboratories of their choice. These laboratory rotations enable students to examine faculty research projects, experimental approaches and laboratory environments, and to select an area for specialization. After completing M2, students are required to take the USMLE Step 1 exam, followed by one or two required M3 clinical rotations lasting six to eight weeks in total. They then transition into graduate studies.
During the first year of graduate training (G1), students take graduate courses selected to optimize their training and devote time to independent research under the guidance of a faculty adviser. During G2 and subsequent years, most effort is devoted to independent research, as part of the course requirements are satisfied by the M1 and M2 M.D. curriculum (see below). On satisfactory completion of course work, students must pass written and oral comprehensive examinations to qualify for degree candidacy. Candidacy examinations for the dual M.D.-Ph.D. are normally completed during G2. Following admission to candidacy, each student must conduct a substantial original research project, prepare a written dissertation, present their work in a seminar and defend it successfully in an oral examination. Department-sponsored seminars and other activities give students opportunities to discuss their research interests with visiting scientists and to present their research both internally and at national professional meetings.
The Ph.D. component of training in human genetics for M.D.-Ph.D. students normally takes at least three years to complete. Courses taken during the M1 and M2 years of medical school satisfy a number of core course requirements, and additional elective courses are completed in the G1 year. M.D.-Ph.D. students, if eligible under NIH rules, are required to prepare and submit an NIH F30 predoctoral training grant application, which is usually based on the dissertation proposal defended during the candidacy examination. This exam comprises two parts, a departmental comprehensive examination and a written NIH-style application with an oral examination administered by the student’s graduate committee. Students also are encouraged to submit predoctoral training grant applications to other funding sources. Acceptance of a peer-reviewed first-author (or co-first-author) manuscript in a scientific journal indexed in PubMed or Web of Science that is based on experimental research conducted during Ph.D. training (rather than a review, commentary, case note or similar publication) is required of all M.D.-Ph.D. students prior to returning to the M3 phase of medical school.
In addition to completing VCU School of Medicine requirements for the M.D. degree and the general VCU Graduate School graduation requirements, students must complete a minimum of 86 credit hours for the Ph.D., including directed research.
Curriculum requirements for the M.D.
Based on the equivalent knowledge acquired by successfully completing MEDI 100, MEDI 150, MEDI 200 and MEDI 250 and IBMS 651 and IBMS 653 during the M1 and M2 years, 13 credits are satisfied (for HGEN 501, HGEN 606, two credits of HGEN 610, two credits of HGEN 690 and five credits toward two electives). Courses taken to satisfy Ph.D. requirements do not satisfy M.D. requirements.
Curriculum requirements for the Ph.D.
Based on the equivalent knowledge acquired by successfully completing MEDI 100, MEDI 150, MEDI 200 and MEDI 250 and IBMS 651 and IBMS 653 during the M1 and M2 years, 13 credits are satisfied (for HGEN 501, HGEN 606, two credits of HGEN 610, two credits of HGEN 690 and five credits toward two electives). Students are required to take additional credits of M.D.-Ph.D.-specific courses listed below.
|Course ||Title ||Hours |
|HGEN 501||Introduction to Human Genetics (satisfied by M1/M2 study)||3|
|HGEN 502||Advanced Human Genetics||3|
|HGEN 510||Classic Papers in Human Genetics||1|
|HGEN 606||Introduction to Clinical Genetics (satisfied by M1/M2 study)||1|
|HGEN 610||Current Literature in Human Genetics (two credits satisfied by IBMS 651)||7|
|HGEN 611||Data Science I||3|
|HGEN 690||Genetics Research Seminar (two credits satisfied by IBMS 653)||8|
|IBMS 600||Laboratory Safety||1|
|BIOS 543||Graduate Research Methods I||3|
|or HGEN 651|| Statistics for Genetic Studies I|
|HGEN 614||Pathogenesis of Human Genetic Disease||3|
|IBMS 624||Research Reproducibility and Transparency||1|
|IBMS 651||M.D.-Ph.D. Journal Club (one-credit course, required fall and spring semester of M1; satisfies HGEN 610)||2|
|IBMS 652||M.D.-Ph.D. Science and Disease||1|
|IBMS 653||M.D.-Ph.D. Research Seminar (0.5 credit course, required fall and spring of M1, fall of M2, and during G phase except in semester of defense; satisfies two credits of HGEN 690)||2|
|IBMS 697||M.D.-Ph.D. Directed Research (three credits taken summers after M1 and M2; satisfies six credits IBMS 620)||6|
|OVPR 601||Scientific Integrity||1|
|or OVPR 602|| Responsible Scientific Conduct|
|or OVPR 603|| Responsible Conduct of Research|
|HGEN 697||Directed Research in Genetics (variable course; required each semester)||39|
The minimum number of graduate credit hours required for this degree is 86.
Plan of study timeline
The dual-degree program blends medical and graduate training supplemented with M.D.-Ph.D.-specific course work and opportunities during the medical (M) and graduate (G) phases of the curriculum that culminates in the simultaneous awarding of the M.D. and Ph.D. degrees. The timeline of medical and graduate training is as follows:
Year 1 (M1): Mostly preclinical medical course work, some research
- Preclinical medical courses
- M.D.-Ph.D. Journal Club (two semesters)
- M.D.-Ph.D. Seminar (two semesters)
- Research rotations (and pre-matriculation research opportunity)
Year 2 (M2): Mostly preclinical medical course work, some research and clinical rotation
- Preclinical medical courses
- M.D.-Ph.D. Science and Disease (one semester)
- M.D.-Ph.D. Seminar (one semester)
- Research rotations
- Preparation for USMLE Step 1
- Required M3 clinical rotation(s) (one or two, lasting six to eight weeks total)
Year 3 (G1): Graduate course work and research, some clinical experiences
- Graduate program course work
- M.D.-Ph.D. Seminar (two semesters)
- Directed research (begin dissertation research)
- Opportunities for clinical experience
Years 4-5 (G2-G3) and additional year if needed: Primarily research, some clinical experiences
- Ph.D. Qualifying Examination, admission to candidacy
- Submit NIH F30 fellowship application
- Directed research (completion of dissertation research)
- Graduate program course work
- M.D.-Ph.D. Seminar
- Required M3 ambulatory care rotation
- Publication of peer-reviewed first-author paper
- Dissertation defense
Years 6-7: M3-M4: Completion of clinical training, clinical research experience
- Clinical rotations
- Clinical and non-clinical elective
- Preparation for USMLE Step 2
- M4 Clinical research capstone project
Rita Shiang, Ph.D.
Associate Professor and graduate program director, Department of Human and Molecular Genetics
C. Suzanne Finley
Graduate program coordinator
Program website: gen.vcu.edu